Originally Posted by alienangel

Just a thought, I believe you can use "mouseover" as the target designation in a macro too. So if you only want to target a different mob for a single ability, you should be able to just mouse over it (raid icons and a tooltip mod that show raid icons make this easier) and hit a keybind for a macro that uses mouseover targetting. I've never done it myself, but if it still works I'd think it would be handy.

I keep meaning to make a /cast [target:mouseover] Silencing Shot macro, but never get around to looking up the syntax.