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In Dark Age of Camelot, any kind of disease debuffs work like Mortal Strike. Wound poison kinda does the same thing, but there aren't nearly enough PVE applications for this, which means it's a rarely used PVP poison. For PVP, I almost always use crippling and mind-numbing. More mobs need HoTS that have to be negated, out-DPSed, or dispelled, imo.
I'd love to see more reactive combo chains. In DAOC they are the norm, and produce staggering results. Of course, pulling them off isn't easy, especially in PVP, and I don't think WoW devs want to go down that road because it: a) requires trusting the client, b) is too confusing for newbies (roughly 7 million people).
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