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I haven't seen any conclusive testing one way or the other. All my experience is "anecdotal" with my mage and shaman and not really worth mentioning.
As far as the limited testing that people have done with spell pen + mages the "agreed upon" conclusion was that COE/COS removes the resists, not that mobs don't have resists. As far as damage gains on a mob with resistance I believe it's pretty cheap item budget wise.
That being said I like -20 resist on a cloak over the other available enchants. I wouldn't socket my gear for penetration though.
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