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For pvp purposes I've added a whole bunch of debuffs and set them to different priorities, UA being 99, Seed of corruption being 98, then ticking down the list according to debuffs which i want to dispell the most. It's really only useful in av or eots, but never mind small details like that:p
As for pve, i've set up lots of encounter specific spells (conflag, static charge, insidious whisper etc) to go on the centre text 1 bar in big red letters (covering the name), which still leaves any dispellable debuffs shown on the centre icon.
The grid manabar mod is pretty nice if a little buggy, and the pet addon mentioned above is again pretty useful, if a bit annoying. For a soullinked encounter i'd usually set the pet to focus target, and on voidreaver type encounters i'd set the pets as playertargets, mainly cos my grid is designed to fit in a small space which the pet addon fucks up:p
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