Originally Posted by Arelenda
- You never want to lose a single tic of unstable mutation, corruption or agony.
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Erm?
Also, in general you should always gear hit first for bosses, then focusing on spell damage (according to the spreadsheet it gives you more DPS than crit, even with Ruin).
Here's a good site for your trinket choices.
SimulationCraft/Trinkets/Warlock - Shadowpriest.com Wiki