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I think choosing between mp5 and spirit is somewhat of a personal choice and also somewhat dependant on which group you are normally in during raids. I've tended to lean toward more spirit stacking and am sitting at ~630 spi/140mp5 unbuffed. Because of this I have established a spot for myself in the MT group and rarely find myself in a different group. Mana never is really an issue for me thru buffs and flasks/pots I normally find myself using 5-10 mana pots a night when things are going well. I would say though if you are not going to be finding yourself in the MT group then to stack mp5 until you find that you have enough regen to last those really long boss fights without going oom and then start stacking the spirit.
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