Originally Posted by Smurrf
This also works extremely well for getting rid of mistimed CoD's. Ever since I got splatted by a mistimed CoD on Nightbane, I've kept CoS handy for just this purpose. Hydross and tanking Leo have already proven to be scenarios where it's come in handy...really sucks when boss timers are off.
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Overwriting damage curses with other ones is also helpful when on those mobs that spell reflect, that like to throw it up just as you're re-applying your curse (I'm thinking specifically of some of the heroic coilfang instances). Bonus: getting a Curse of Recklessness on yourself during the packs where you might potentially get feared.