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Well, since M'uru-specific discussion is still taboo, I'm going to pass on giving M'uru-specific information. Anyone who wants specific M'uru information is free to PM me, but for purposes of the public forum that topic is still off limits.
In terms of the more abstract question around dealing with trash and multiple low-level boss adds, my answer would be this: First, hit over 299/307/315 is largely wasted (yes, you can gain partial benefit from an additional point above those numbers, but in general it's not ideal to do so) against level 70/71/72 mobs. Hence, it is advantageous to your hit rating below this level. However, once you're safely below that level, there is still no "magic" amount of hit to aspire to; hit is still a valuable stat, and should be used accordingly. The value of hit may drop somewhat, of course, depending on the interrupted-ness of the combat; but you should still use the best gear available regardless of the exact amount of hit it may happen to have - it's just that the "best gear available" may tend to have slightly less hit on it.
The obvious follow-up question, of course, is how much the value of hit drops when you're in a trash-type scenario. The fundamental answer is: not that much. If you search, you can probably find a post I made a while back which asserted that in a fight where you're 30 seconds in 10 seconds out, the value of hit is only about 5% lower than in a 100% time-on-target fight. So hit may drop in value by .1 to .15 EP... but that's hardly an earthshattering change. Hit is still good, so don't go overboard with dropping it. Particularly since not all trash situations are nearly that interrupted - 30 seconds is probably on the right order of magnitude for time on one mob, but it takes nowhere near 10 seconds to move from target to target in most cases. So hit probably doesn't even lose that much.
The stat that does tend to lose value in trash situations is ArPen. In multimob situations, it's rare to be getting CoR, and you're unlikely to be getting both Sunders and Faerie Fire. Moreover, EA tends to be a bad choice, as by the time one gets a 5-pt EA up you've already half-killed the mob. So, while on Brutallus there tends to be 4000-4500 in armor-reduction debuffs on the boss, in trash situations it's rare to have much more than Sunders (2600). Hence, the overall armor value of trash tends to be somewhat higher, which in turn reduces the value of ArPen.
The level of interruption also determines the value of proc trinkets. WSC, for instance, is all about the proc; if you spend half of a proc running from one target to the next, the value drops in a hurry. So if you're mostly going straight from mob to mob with only a second or two in between, a low-uptime proc trinket like WSC can be quite good; however, if interruptions are frequent, you're better off with either a higher-proc rate, passive, or activated trinket. I'm also of the opinion that AToL is not generally a good choice for this sort of fight due to the tendency towards unstable cycles.
So, all in all: getting below the hit cap is good; dumping hit in a significant way outside of that is bad; ArPen becomes less valuable; and low-uptime proc trinkets tend to be bad in trash scenarios. The exact balance of these influences depends on exactly what you're fighting and the way your guild sets up the fights (buffs, debuffs, positioning, etc.).
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