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With merged CoE, Malediction on its own is almost a wash compared to the affliction lock's output, but there might also be a minor negative impact on the raid ISB uptime. An affliction warlock loses 3% crit from backlash, and possibly some more from regemming although they might have the same optimal gear set. The ISB uptime change from 3% crit is almost microscopic, but it's about the same order as the difference between affliction and destro when accounting for merged malediction. But, as we've said, the point is not malediction, malediction just lets you make up some of the loss you take for getting Shadow Embrace.
If I remember right, one single amped CoD is better than a destro CoD, but the average over time of affliction CoD with Amp Curse (ie one amped and two regular) is not. You're comparing 16.7% base damage to 15% base damage and 15% spell damage, destro wins because DS is the only thing that effects CoD's scaling.
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