Originally Posted by Jayde
That's probably a bit situational. Good example would be Slave Pens... I'd kinda prefer to have a main healer that could actually remove Quagmirran's poison rather than one who couldn't. I found this boss substantially easier with a Druid healer compared to a Priest.
Other places, that isn't always the case. Really depends on which parts of their versatility you need.
I must admit that I really do love a Shaman main healer that can pop Heroism. 
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Hey Jayde
Anyway, I'd agree to a certain point that Hybrids have an edge over the "pure-one-way-classes". I did a few Heroics as Enh Spec and I loved it. Bring both sets of gear, switch accordingly. Things go wrong? Pop in a few heals. Bring utility with you, that's what being a hybrid is about and it's awesome.
Our usual setup for Heroics is filled with Hybrids, come to think of it.
Feral Druid
Resto Shaman
Shadowpriest
Random CC class
Random CC class
Had no extreme issues with most instances, however stuff like Shattered Halls is quite tough, ofcourse. But doubt that's due to the groupsetup.
However, think out of the box while doing heroics. It'll save you time

We've done heroics with such rediculous group setups, but with improvisation you can do a lot. We cleared Shadow Lab a while back with:
Enhancement Shaman
MM Hunter
Holy Paladin
DD Warrior
Prot Warrior
Needless to say, it was quite the cracker. The Blackheart room was just really hard, until we used our head -> Hunter pulls 3/6 mobs to him with Multishot and kites them to the entrance. The 4 of us deals with the 3 others. Hunter reaches the instance portal, feign.
Repeat. Success.