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1) Any fight for which you are not overgeared. No kidding we don't need elaborate mana conservation strategies today, for content we mastered months ago. But when we were learning Ragnaros, Broodlord, or Firemaw, to name a few, mana was very much an issue.
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I don't know, none of those ever really depended on mana for us. Ragnaros was too short for it to matter much for the dps'ers, and most healers were outside of wand range due to having to spread out. Broodlord is also quick enough that it didn't matter much, but then we never fought him in his 100% aggro-wipe form. He might have been trickier then. On Firemaw it's counterproductive to use JoW for healers, since the mana used to heal away the AoE damage you take will be higher than what you gain from it. The dps'ers are aggro limited rather than mana limited.
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2) Any fight where aggro is a major concern. JoW gives Alliance hunters a massive advantage over their Horde brethren in damage output, and since hunters are essentially zero-aggro DPS, that's significant.
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I have to admit I've not played a raiding hunter, so I don't know how big the difference is, but I assume it's quite decent. Unless you bring an abnormal amount of hunters though, it's a relatively small raidwide increase, but it could be significant.
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3) In practice, recovering or stablizing any shaky situation on nearly any fight where something goes wrong. An Alliance priest can wand back up to workable levels of mana far faster than his Horde counterpart.
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Yes, I mentioned this. This is not really something that makes encounters easier though, it simply provides a safety net (one you rarely have the luxury of being able to use on non-mastered content).
But yes, it definitely does have potential to make a big difference, it's just that in our experience, it's been more "handy" than "necessary".