I can't click c faster than 6 because of my freakishly long fingers, haha. For someone looking to change from majority of clicking I would definitely suggest this, but I've been using this set up for 3 years and to change would take forever to get used to and lower my performance (especially since I plan on tanking/healing and your skill rotations while leveling are completely unreliable compared to those for endgame), plus I'd get carpal tunnel if I tried to constantly click the letter keys and alt+letter keys rather than the Numeric above the letter keys (that extra inch allows for a nice grace of movement for my fingers).

personally i prefer for a long long time with shaman (resto):

1,2,3,4,5,6,q,e,f,g,t,v
+strg (1,2,3,4,5,6,q,e,f,g,t,v..)
+shift (1,2,....)
+alt (a.s.o..)
every button is in range of my crappy long fingers so i can use every spell i need w/o unhandily handmoves
+mouse4,5 for trinkets or some other needed stuff

i reassign some important skills to strg1-5 for some encounters

Main benefit of bindpad is it never seems to break due to patches, ever. Probably because it's so simple.

Rogue, ESDF/Mouse to move. Mutilate spec.

1-Dismantle
2-Mutilate
3-Eviscerate/Envenom (I switch them out)
4-Gouge
5-SnD
Shift+3 - Rupture
Shift+4 - Evenom/Eviscerate
Shift+G - Expose Armor
Shift+F - Shiv
Shift+V - Feint
Shift+Space - Hunger for Blood
A - Arcane Torrent
Q - Kick
W - Kidney Shot
R - Evasion
G - Cold Blood
Shift+R - Cloak of Shadows
Z - Blind
X- Vanish
Shift + C - Deadly Throw
Num+/- - Throw
Numpad Enter - Sprint
Shift+W - Pot/Healthstone
Shift+T - Trinket/Thistle tea
Shift+D - Drums of Battle

Does anyone use the autotarget-self modifiers in the default UI? (eg, alt = cast spell on self)

I keep looking at that and wondering if it's a good idea, vs just binding a macro for the most crucial
"panic button" stuff like I do now with things like lay on hands for a tankadin. It would save keys
but I'd have to use a chord in a panic button situation instead of a key.

Same question I guess about the auto focus modifier which casts on focus target automatically instead
of just making a focus-sheep type macro.

Has anyone had success doing his? How long did it take you to adjust?

Here's how I do it:

I have self-cast always turned on, then I use mouseover macros for pretty much everything that can be cast on anyone.
Here's my layout. Everything underlined has a mouseover macro.
(using Mouse 4 as ALT and Mouse 5 as SHIFT)

Movement = RDFG

One row on the keyboard at a time:
1 = Divine Intervention
2 = Lay on Hands
3 = Righteous Defense
4 = Holy Light
5 = Flash of Light
6 = Sacred Shield
7 = Divine Plea
8 = Exorsicm
Alt+8 = Turn Evil
Shift+8 Holy Wrath
Shift + 1 through 7 = auras

Q = Autorun
W = Consecrate
Shift+W = Shield of Righteousness
E = Judgement of Light
Shift+E = Judgement of Wisdom
Alt+E = Judgement of Justice
T = Crusader Strike
Shift+T = Divine Storm
Alt+T = Hammer of Wrath
Y = Arcane Torrent
Shift+Y = Seal of Righteousness
U = Hand of Protection
I = Divine Shield
Shift+I = Divine Protection
O = Avenging Wrath + trinket 2 macro
Shift+O = Hand of Salvation

A = Seal of Wisdom
Shift+A = Seal of Light
S = Repentance
Shift+S = Seal of Blood
H = Hammer of Justice
Shift+H = Seal of Command
J = Seal of Justice
Shift+J = Seal of Corruption

< = Jump
Z = Hand of Freedom
Shift+Z = Hand of Freedom on arena partner 1 macro
Alt+Z = Shift+Z = Hand of Freedom on arena partner 2 macro
X = Hand of Sacrifice
B = Trinket 1
Shift+B = Trinket 2

Spacebar = cleanse
Shift+spacebar = Cleanse arena partner 1 macro
Alt+spacebar = Cleanse arena partner 2 macro

Depending on your mouse, your mouse software may allow you to set one of your mouse buttons to emulate a key.
F.x. I use mouse 4 and mouse 5 to emulate shift and alt. This way I can do double/tripple keybindings one one key.

Example:
Num7 = devastate
Num7 + Mouse 4 = thunderclap
Num7 + Mouse 5 = demoshout

Imentet:

Do the WASD (or better yet ESDF) move. You'll have to do it at some point anyway. You get used to new layout very quickly, faster than getting used to something like moving your unit frames around.

solbergb:

I just naturally assumed that every heal capable class plays with self cast modifier, especially paladin. Self cast modifier works on top of other modifiers, so if you for example have blessing of freedom on SHIFT+W, ALT+SHIFT+W will freedom yourself. It's very convenient and comfortable allowing for very fast response. On my warrior I use the same for focus modifier.

I'm enjoying BindPad the only thing with it right now that doesn't work on it is you can't use the pet tab - the one with the mounts. No big deal at all just create a mount macro. Otherwise no issues at all, the buttons opening macro and spellbook tabs are a very nice touch.

This may belong in a Warrior specific thread, but since I havn't seen anyone mention it I figured I'de share. Some skills have mutual exclusivity in terms of range and are ideal for binding together with extremely simple macros. I watch a lot of warrior pvp videos and I've only ever seen this once, but I bind Hamstring and Intercept to 1. I know there are other classes that could probably bennefit from this (mostly hunters and rogues, any class with instants that stipulate melee only and ranged only) so feel free to give some examples or tell me I'm dumb and that everyone does this. With Intercept/Charge and Hamstring, you can never use one while being able to use the other, so this is ideal for freeing up just one more button.

Thats a pretty good idea, thank you very much i will do this with my hunter combining "concussive shot" with "wing clip"

How would you macro this?

I rerolled resto Druid for the expansion. Here's what I'm using so far, for keybindings.

1: Lifebloom
2: Swiftmend -- Shift 2: Starfire
3: Rejuvination -- Shift 3: Moonfire
4: Regrowth -- Shift 4: Healing Touch
5: Wild Growth
6: Tranquility

Z: This will be my PVP trinket when I finally get one.
C: Cheetah
V: Cyclone
H: Hibernate -- Shift H: Hurricane
I: Innervate
R: Entangling Roots -- Shift R: Nature's Grasp
T: Nature's Swiftness
G: Mark of the Wild -- Shift G: Gift of the Wild
F1: Abolish Poison
F2: Remove Curse
-: Shadowmeld (The minus key on the numberpad.)

I've never been able to use mouse buttons as keybindings. I may decide to change this up soon. I also don't like reaching for numbers higher than 6 on my keyboard. The only other item is "F" and "X". I've just never found a need to re-bind those. I like them setup as assist and sit, as defaults.