Q: What about a single-disease rotation/spec?
A: Those died back in Ulduar when Blizzard made all our strikes %-based scaling off of diseases. Long story short: you lose more damage than you gain, do the math if you don't believe me.
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I have to disagree with this both me and another frost dk are running single disease and are hitting 9k dps single target self buff'd.
if you want to try it its really easy use this spec
12/56/3
Priority is Howling Blast, OB, Blood Strike(to flip runes), Frost Strike to runic dump