I havent checked my combat spec, but I did check posions/weapons for Mutilate.
I ran some quick tests on a heroic dummy to check poison / weapon speed differences going through my rotation for a little over 2 mins on each test (cooldown on Vendetta).
It appears I had better luck using Slow/Fast and IP Main, DP Off. But I also noticed that DP Main, IP Off was almost the same (not sure why). Of course this was only a quick check.
| Main / Off Counts Damage DPS Average Energy Regen |
| 1.4 IP/1.8 DP 680 1006695 7640.4 1480.43 830 |
| 1.4 DP/1.4 IP 754 1045107 8061 1386.08 915 |
| 1.4 IP/1.4 DP 767 1050729 7934.2 1369.92 900 |
| 1.8 IP/1.4 DP #1 747 1084247 8295.7 1451.47 1025 |
| 1.8 DP/1.4 IP 696 1096499 8293 1575.43 970 |
| 1.8 IP/1.4 DP #2 747 1105212 8369.6 1479.53 930 |
| 1.8 IP/1.4 DP #1 Count Damage % Average |
| Instant Poison 208 314988 29.05% 1514.37 |
| Melee 297 233008 21.49% 784.54 |
| Mutilate 70 168744 15.56% 2410.63 |
| Envenom 19 146772 13.54% 7724.84 |
| Deadly Poison 42 93458 8.62% 2225.19 |
| Venomous Wound 45 81653 7.53% 1814.51 |
| Rupture 60 40293 3.72% 671.55 |
| Garrote 6 5331 0.49% 888.5 |
| Total 747 1084247 1451.47 |
| 1.8 IP/1.4 DP #2 Count Damage % Average |
| Instant Poison 215 341707 30.92% 1589.33 |
| Melee 297 244967 22.16% 824.8 |
| Mutilate 72 175468 15.88% 2437.06 |
| Envenom 16 132573 12.00% 8285.81 |
| Deadly Poison 42 94055 8.51% 2239.4 |
| Venomous Wound 38 71895 6.51% 1891.97 |
| Rupture 61 38599 3.49% 632.77 |
| Garrote 6 5948 0.54% 991.33 |
| Total 747 1105212 1479.53 |