Originally Posted by Halstrom
Which bosses or encounters would DS and BoP actually work? Plasma Blast and Frozen Blows warrent use of DS but are not physical damage. With General, Surge of Darkness is Physical damage so using Hand or Divine of sacrifice rotatin BoP and DS is very helpful.
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Yes, Vezax does work, although you should ensure you have your cooldown(s) ready for DS+DiSac when the animus comes up. HoP is also safe to use during the Tympanic Tantrum on XT, Kologarn's shock wave or Thorim (not recommended for the hardmode due to the frost damage flying around). On pretty much all of the other bosses HoP+DiSac would be fatal or at least very risky.