Originally Posted by Shalas
Yes and yes. Every file in your WoW directory that is not absolutely required (including things like screenshots) adds a very small amount of time to startup, and it can become significant if you have a lot of crap there as most people will.
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Moving ~6,000 screenshots and a hundred or so other files out of my WoW directory makes no noticeable difference to my load times (~1.75 minutes).
Disabling all addons however drops loading to about 10s total :o