I've been working on something pretty different for me. Almost all of my UI's in the past have been designed for a raiding healer. I've designed this UI for a dpser who just solos. It's really all it's good for, but it allowed me to do things I couldn't otherwise do in a UI and has been a ton of fun to make.
The main thing about this UI that is pretty different is that there is only one unitframe, and the only bar is for my health. Everything else is text based. However, I've found that focusing on nameplates while trying to kill something is really ideal, so Aloft is used basically as the target frame.
Here's an in combat shot:

And here's a shot that shows the different ways the UF can look:

In the top picture, you can see most the info that ever shows on the UF. The top left is my target. Top right is the Target of Target as long as it isn't my pet. Bottom left shows my pet's happiness and my mana points (this also shows number of pet debuffs if he has any). Bottom right is my name.
The second picture just shows me and my target (I love the way the names are placed, looks pretty cool to me :p)
The last picture is a pretty average in combat shot, showing my targets name/health on the top, my pets health and my mana on the bottom.
Visible addons: pitbull, aloft, bt3, rbuffs, rminimap, pchat, and cowtip.