Sentences start with a capital letter and end with a period, and replying to year-old posts isn't exactly a good idea.
Originally Posted by Sculduggery
Since Venomous Wounds affects Garrote, opening with Garrote is going to result in more damage and energy return than opening Mutilate when it is viable. There are going to be situations where it is not possible to pre-pot + re-enter stealth then Garrote, but in situations where it is viable (Saurfang/LK), you will want to use Garrote.
The question isn't whether is more DPS to chose to open with either Garrote or Mutilate. The question is whether it's more DPS to open pre-pot or Garrote.
Depending on your micromanagement skills, using Vanish for the Overkill during combat should always be broken with Garrote now; the reasons being the same. I assume you could macro something like this: