Originally Posted by PSGarak

I really doubt the runes are actually going to be tied to the equipped weapon. Describing runes as scribed into your weapons is mostly a lore thing, and I'm wouldn't be surprised if they change runes to be tatoos instead of weapon glyphs, rather than tie them to the currently-equiped weapon. The biggest arguement I can see in favor of it is that you put a tank rune setup on a tank weapon and ditto for DPS, but I really do think that tank setups are going to be more varied than that depending on what sort of utility/snares/interrupts you might want.

EDIT: I'd also like to not need a different tank sword for each gimmick boss in naxxramus. Especially if DW-tanking is buffed and I actually need two swords per boss.