Originally Posted by Tel

I would recommend making macro's to DE and then you can just have it in a small window and mash the button while watching a movie or something.

The macro most use is

/cast disenchant(ing?)
/use Item name

Its common knowledge by now I assume, but I see no harm in repeating it for those that havne't picked up on this tip to make it slightly less suicide inducing.

The same can be done for prospecting or milling and is worth using if you're making any significant number of items.

Edit: Make sure you have auto loot turned on