I have been using Magic Rune for over a week now, and it works decently enough for me, but I have a hard time with the DDR style scrolling of the graphics drawing my eye too far away from debuff cooldowns.
This is just a quick graphic I whipped up which shows what would likely work better for me (and possibly other people). This is a larger than I would have on my screen (I would put it about half the size), and the animation is choppy because I don't have the time to do it frame by frame,but it should give a good idea.
Notes
-With death runes, the frame takes on a gray color
-Instead of having the bar fade from black, cooldown could be indicated by black moving horizonal like timer mods
-Cooldown timer could be disabled or placed inside frame
-Runic power bar (thin horizontal) could be added to top/bottom of this frame
-Use of mod like debuff filter can place disease timers directly above or below this bar
-Flash (indicating cooldown finished) could be more subtle
-Enabling symbols inside the frames for added clarity (and help the colorblind)
-Someone with better color design talents than I can make the red, blue and yellow a more interesting color)
So if there is an addon maker who likes this design and wants to run with it, go for it.