I'm using the 52/0/20 spec with the bloodworms, and I haven't run into any problems caused by the worms. However, I OT all the multitank fights in the 10 man so I can only safely say for Hodir, Mimiron, General, and Yogg. Out of all these fights I'd think Yogg and Mimiron would be potentially the most precarious if the worms were to cause any trouble (proximity mines and green clouds in P1 respectively).
In the end, after getting the pure DPS talents in the blood tree, Blood Worms is the only filler talent that will actually give you more dps. Granted I get 80 or so on a typical fight but its better than 0 lol.