I haven't seen anyone suggest this, though it is unorthodox. I'm on the PTR atm, and I don't have the weapons to legitimately test this, but I'm curious toward this spec... with a reasonable amount of ArPen, spamming Blood Strike and Obliterate being the basis here. I'm unsure about Glyph of Disease, but I need to fix all my addons before I can test anything and post results.
Scent of Blood and Death Rune Mastery are useless, but I don't know where else to put the points.
Stacking Hysteria and Unbreakable Armor during Heroism would yield some ungodly dps.
The new sigil that procs 200 str has 100% uptime, by the way. Not sure if they overlooked an internal CD or what.