Originally Posted by Teme
I don't know...diseaseless is still very viable and unless you have 4p T8 diseases are too much hassle.
Assuming you have obvious glyphs and talents
DS, HS, DC repeat is still working wonders.
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I ran some math on this the other day in attempt to prove that diseaseless wasn't really viable, and much to my surprise, that's not really what the numbers showed.
Assuming a blood w/ diseases rotation of:
IT PS HS HS DS <dump>
DS HS HS HS HS <dump>
and a diseaseless rotation of:
DS HS HS HS HS <dump>
HS HS DS HS HS <dump>
Both rotations generate the exact same amount of runic power (not counting IT glyph if you use it), though the diseaseless spec would free up points in epidemic for points in ravenous dead or morbidity, depending on your preference, but more on this later.
For w = weapon damage and assuming 33% crit, the damage done over 3 rotations from rune abilities (approximately a minute) will be on average
diseaseless: 36.66w + 22217.68
w/ diseases: 36.23w + 22104.77 + 2.38ap
Increase the crit to 50%, and you get
diseaseless: 42.63w + 25837.42
w/ diseases: 42.10w + 25625.86 + 2.43ap
To get w, you have (Wdps + (1/14)ap)*3.3 (3.3 is normalized 2h speed). In the case of a Betrayer and 4000ap, you have w = 1678.43 average damage. In order to account for death coil damage, let's assume a spec of
51/0/20 for blood w/ diseases. To make that diseaseless, move the 2 points from epidemic into morbidity. Each rotation will generate 110 RP per iteration, though diseaseless will generate more DCs via sudden doom. On average, diseaseless will generate 11.85 DCs that hit harder than blood w/ diseases' 10.95 DCs. All together after 3 rotations, using a Betrayer with 4k ap, ability damage will be around
.......................33% crit (dps).............50% crit (dps)
diseaseless: 104543.24 (1742.4) 120841.14 (2014)
w/ diseases: 109902.48 (1831.7) 125708.73 (2095.1)
I include calculations for two values of crit to illustrate that the value of crit is bigger for diseaseless than for blood w/ diseases, but that the difference isn't nearly enough to magically make diseaseless effective (even at 100% crit). In addition, you have to factor in an extra 9% physical damage from BV and an extra 4% damage on everything but IT, FF and BP (clearly favoring diseaseless). Adding those in yields an overall change of less than 5dps in the difference between diseaseless and blood w/ diseases.
In conclusion, the math presents that blood w/ diseases is the optimal dps rotation, though not by a huge margin. In practice, it comes down to whether you can squeeze all of the HS into the disease timers consistently, which depends heavily on the amount of target switching/moving around that has to happen in a fight.
(Disclaimer: Keep in mind that the above math assumed no raid buffs, assumed hit cap and didn't factor in for armor mitigation, which would make minimal differences at best, seeing as how both rotations are heavily reliant on physical damage.)