Originally Posted by tetracycloide
I see this thrown around a lot as a 'good' indicator of when Pest should be used but 3 seconds is astronomically high. Unless something else, fight mechanic wise, would prevent you from doing so 1 second left on diseases is probably more than necessary unless MS is over 1000.
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Rather than living on the edge and hoping I manage to use pestilence at the exact time I need to use it, using it one GCD or so earlier is a lot less stressful.
Using Pest on the last second can easily come into conflict with the GCD. With 21 second diseases, you can fit in 14 GCDs. However, even a little bit a latency can mess that up a little, not to mention haste lowering the GCD for spells like IT and DC changes things even more. Unless you're focusing mainly on your GCDs, if you want to save Pest for the last second it seems pretty easy to be able to misjudge and only get it off by the skin of your teeth or else not make it in time at all.
So, while I definitely wouldn't argue with you that using it at the last second would be the most optimal way to utilize Runes, it doesn't leave a lot of room for error. Three seconds gives you wiggle room without sacrificing much at all.