Originally Posted by Grigori
Disease dropping is an overall DPS increase in this case. If you reapplied the disease at the 20+latency-sec mark, the disease would tick 5+latency seconds from the previous tick (which is very close to the worst-case scenario for a refresh); if you reapplied the disease at the 30+latency-sec mark, the disease would tick 3+latency seconds from the previous tick. As long as you reapply BP first, your IT will get the RoR bonus. Over a 60-sec rotation, you effectively gain 4 ticks of disease, which is significantly more damage than you lose from no RoR bonus for PS.
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Napkin Math:
With Epidemic und SS - Asuming BIS Ulduar Gear
You will gain approximatley 500 dmg (SS > IT + PS) - 9 dps
You will gain 2 Disease Ticks (appr. 1200 dmg each) 2400 - 40 dps
You will lose 5 Runic Power, that´s roundabout 1000 dmg. (1/8 DC+UB) - 16 dps
You will lose 10% dmg of your 2xPS (appr. 600 dmg) - 10 dps
You will loose 10% of your Blood Plague (120 dmg each x 18 ticks) 2160 dmg - 36 dps
You loose about 13 dps... These numbers are far from accurate... but there is a small dps loss...
Should your diseases drop for only 0.5 sec the impact on your Raid´s dps will be another factor.