Originally Posted by Riemu
I dont get how you guys can play with such a tiny/cleaned up UI
Im trying to optimize my UI constantly and i would love to have more space and a cleaner UI but i cant figure out how
Somehow i need all of those things / buttons I have
Here's my UI, maybe someone got an idea on how to make it more neat 
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Making a minimalist UI is about learning what you NEED to have and eliminating/hiding everything else. When I redid my UI, I took special attention to keep track of which buttons I needed to click in combat/out of combat, which ones I used a lot/ a little, etc. You have 50 buttons on your main bars, but I am willing to bet you don't click cast many of them, so why show them? Use macros to combine buttons, like the all-in-one trap macro using modifiers, or the pet revive/call/feed/dismiss macro. Take all of the buttons that you still have to have, but don't use in combat and hide them off on the right side of the screen, making them only appear on mouseover.
You might want to switch out your detailed party frame for a simple raid frame showing small health bars, or "grid" style boxes if you like that. Individual buffs/details on other raid members are unnecessary details for a hunter. You might change your buffs to the more classic icon with a small timer, which takes up a lot less space than a bunch of timer bars, which don't really gain you anything while in combat. Your recount and omen windows are much bigger/opaque than they need to be to display the same amount of information.
Not everyone prefers to play these games. It is guaranteed that doing so requires you to maximize the use of key binds, macros, and the ability to use all of them without having to click buttons (which is a good goal to work towards anyway. Really though, go with whatever is the most comfortable for you. Good luck!