Mine is similar to many on here it seems, but I use a small, in-combat-only bartender bar with omnicc to track cooldowns on my main shots. It's the smoothest solution I have found for keeping my best shots firing without delay.
Bartender - bars
Omnicc - cooldowns
Quartz - cast bars, autoshot, target debuffs
Pitbull - Target and Player units
MSBT - debuff alerts, scrolling battle text
SexyMap - minimap
Skada - threat/damage