Guess I'll chime in here. I overhaul my UI every couple months, but this is what I'm running with now. Focus frame goes to the left of my player frame.
Visible stuff is: Pitbull4, Quartz, SexyMap, EBB, Bartender4, Skada, Scorchio2, SLDataText, StatBlockCore, MSBT, kgPanels, Chatter, Grid, and BigWigs.
Looking over a lot of UIs here, I have a few comments. First, if you're using Arcanum or Cryolysis (or whatever the mage mods are these days), try OPie. You get all of the same functionality (likely gain some) and don't lose any screen real estate in the process. It's really a large improvement.
Second, I highly recommend Skada in place of Recount. Skada isn't quite as feature-rich as Recount, but it's much faster and massively lighter in terms of memory usage. I made the switch right after Ulduar was released and I'll never go back to Recount.
Third (thanks to Kyth for this one), in my guild the mages do a large amount of respeccing for Ulduar. In any given week, I run two versions of Fire/TTW, FFB, Arcane, and two versions of Frost. I started using
ActionBarSaver which pretty much keeps me sane when flipping between specs and swapping macros and such. It's a godsend.