What is the most advantageous opening for Combat now?

[Subterfuge]+Ambushx2->SnD->RvS (4pt SnD)
[Subterfuge]+Ambushx2->RvS->SnD (5pt SnD)
[Shadow Focus]+Ambush->RvS->SS->SnD (4 or 5pt SnD)
[Shadow Focus]+Ambush->SnD->RvS (2pt SnD)

My initial thoughts were to go with the latter, getting SnD up ASAP and with the free Ambush I am getting a 2pt SnD for free and wasting minimal energy due to capping at the start. This also lets me go into normal rotation at full energy.
However, if the damage is enough, fitting in 2 Ambushes via Subterfuge gets me a longer SnD, but has me energy starved at the start of the fight. Likely would be fine if you start with that and immediately go into KS or AR on a single-target fight.

As an afterthought, I am guessing for Combat, Ambush > Garrote regardless of your choice in opening rotation.

(Not sure if this post belongs in here or in the Simple Questions thread for Mists, since we dont' have a new Combat thread up yet.)

Do not use unglyphed killing spree on madness, you will teleport into the water.

You won't die from being down there though, but you will have to recuperate and feint. You can be pulled up by priests from the backside of his head.

Happened to me on madness LFR testing UI.

edit: clarified unglyphed killing spree used.

Perhaps with the implementation of the new Killing Spree Glyph Blizz has modified fights like Madness and Ultraxion to which you are forced to use the glyph.

I have not had had a chance to try it as I have been chest deep in code this week.

I have tested and with the glyph you do teleport where you have started from...I feel this is a must, just need to be certain when to Killing Spree.

I used unglyphed KS on Madness yesterday night. I was teleported behind his head while KS was going on, and then back to the land in the middle of the platform once it had finished. (Madness HC, European Realm, Weds 29th). I don't think it is as simple as just "You need the glyph now.", though given other poster's issues whatever the intention behind the fight, the glyph seems like a safe call.

Has there been any rough numbers yet on how much uptime you need on a target out of the 18s before using RvS becomes a DPS loss?

I used KS on both Ultraxion and Madness yesterday, without the glyph I had the same happening.

Ultraxion : no change, still KS-ing in front of him without moving

Madness P1 : no change, still not moving on plateforms 2 & 3, and "climbing" the limbs on 1 & 4

Madness P2: went behind the head, resulting in going back and forth because of the "wind jump" between plateforms. I ended up where I started the spree, but it was because of the carrying winds in my opinion (looked like I was landing on the plateform rather than reappearing in front of the head)

Overall nothing changed without the glyph on those bosses.

I was noticing the quickening of stacks as well, but wrote it off as anecdotal evidence based on not playing with daggers for a while. Not that it matters all too much since Mop is less than a month away, people might as well play what spec they prefer at this point.

As Sakuratei said this isn't a huge difference here but the daggers as of now do stack incredibly faster (how much exactly I'm not sure) AND they also proc off of Fan of Knives for whatever fight you're using it on as far as I've seen.

I haven't actually ran numbers on what's best at 85 simply on the fact that it won't be here for much longer but I'd suggest playing everything if you haven't tested on Beta to get a relative feel for the specs as they are each slightly different now.

Just thought I'd mention, that after a few tests, 2.6/2.6 still has no chance against 2.6/1.8.

Something everyone probably forgot about with having the Legendary Daggers.

Deadly poison is not on PPM mechanic, it has a fixed chance of application. I don't think this was changed in any way in 5.0.