Long time reader, first time poster. I love your spreadsheet, it's done miracles for me as well as the rogue community in general.
First a bit of background, I am usually combat 7-51-13 with fist/sword. I have just about the best possible pre raid gear except for shoulders from naxx.
This is my armory.
The World of Warcraft Armory
First the fast question.
I usually run wound/wound poison, even though the spreadsheet says that wound/deadly is better. However, experimenting with this I set the fight time to 10 seconds. Even in a 10 second fight it says deadly comes out on top, which makes no sense to me. In almost all my real fights (Instructor Razuvious for example) I find 2x wound will do a larger % of my DPS than wound + deadly. Kinda lost here... (2.6 fist with wound, 1.5 sword with deadly)
Now for what really confused me.
With the fist/sword spec, I started experimenting with where to take out points so the combat tree would have 51.
With sword spec at 4/5 my DPS is at 4367.1. (spreadsheet value, I can only dream of that DPS for an extended fight)
With CQC at 4/5 and sword spec at 5/5 my dps is about 4367.6. Fine, that's believable.
However, if I go 1/2 imp SnD and 5/5 fist, 5/5 sword my DPS is 4389. Taking that 1 point out of imp SnD lowers my DPS by 0.08. Taking the second point out drops it by over 50. The only conclusion I'm getting here is that there are times with combat where both rupture and slice are (hypothetically) around 8 seconds and the energy bar fills, which forces me to refresh slice/rupture. Does taking the point out of imp slice clean up the slice/rupture rotation? IMO the spreadsheet wins here, but perhaps I could get some clarification.