Originally Posted by Tinwhisker
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It should be noted, though, that Heartpierce's proc is a bit more complicated. It procs due to hits from either hand, not just the one wielding it, and
each hand is 1ppm. If you have Heartpierce MH and a 1.4 speed OH, the MH proc chance is 1/(60/1.8)=0.03, and the OH proc chance is 1/(60/1.4)=0.02333. So every hit with Heartpierce itself has a 3% chance of proccing, and every hit with a 1.4 OH has a 2.3% chance. Note that these figures are not affected by haste; if you get 100% haste (meaning you swing twice as fast as normal) it's still a 3%/2.3% chance for every MH/OH hit.
It also procs from combo point builders and finishers. I'm not aware of anyone having done the testing to accurately identify the chances, but it's a good bet that it just reuses the 1ppm chances.
Last but not least, poisons proc it too. I didn't test anything but IP and DP, but I did prove that it procs from both of them (note: only from DP applications, not from the DOT ticks). In fact, it double dips: when you're at a full 5 stack of Deadly and Deadly is reapplied, inducing an Instant proc, Heartpierce can proc from both events. The best known theory is that the chance for a Heartpierce proc from any of these poison events is the same as the melee chance for the weapon which procced the poison. IP procs which are induced by Deadly stack refreshes appear to be calculated with the Deadly hand's proc chance, not the IP hand's proc chance.